Immunomodulatory and antiparasitic effects of garlic–arteether combination via nitric oxide pathway in Plasmodium berghei-infected mice
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منابع مشابه
Plasmodium berghei: antiparasitic effects of orally administered hypoestoxide in mice.
Hypoestoxide (HE) is a diterpene isolated from Hypoestes rosea (Acanthaceae), a plant indigenous to Nigeria. Previous studies demonstrated that HE exhibited potent anti-inflammatory and anti-cancer activities in well established animal models but weak in vitro activities in both the anti-inflammation and anti-cancer in vitro screening systems. We now report a similar observation in the in vitro...
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Background and Aims: The aim of this study is to clarify nitric oxide (NO)-production by spleen and the importance of spleen in malaria infection in murine model. Materials and Methods: Thirty outbred NMRI female mice were divided into four groups, Group I: No intervention (Healthy control), Group II: With splenectomy (Healthy test), Group III: No intervention, Inoculation of contaminated bloo...
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Background: Pioglitazone is the selective PPAR-γ receptor agonist, which is prescribed for the treatment of type 2 diabetes and may also have antidepressant effects. Nitric oxide (NO) has been involved in some crucial roles, including learning, cognition and neurogenesis as well as some neurodegenerative diseases, including Parkinson, Alzheimer's disease (AD) and depression. Reduced estrogen le...
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Malaria remains o n e o f the leading causes of morbidity and mortality in tropical countries, and the alarming spread of the drugs resistant malaria parasite underscores the need to develop new antimalarial compounds. In this study, the phytochemical constituents, in vivo antiplasmodial, and cytotoxic activity of methanolic extracts of Achyranthes aspera and Ficus thoningii were evaluated usin...
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Background: Newbouldia laevis and Crateva adansonii are popular plants used traditionally in the management of patients with malaria infection in Nigeria. In this study, the acute toxicity and anti-plasmodial effects of the leaf extracts of Newbouldia laevis and Crateva adansonii were investigated in mice. Methods: The Anti-plasmodial activities of both extracts were investigated individual...
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ژورنال
عنوان ژورنال: Journal of Parasitic Diseases
سال: 2019
ISSN: 0971-7196,0975-0703
DOI: 10.1007/s12639-019-01160-0